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KMID : 0613320090150010026
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Journal of the Korean Bone and Joint Tumor Soceity
2009 Volume.15 No. 1 p.26 ~ p.33
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Clinical Significance of Maspin Expression in Osteosarcoma
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Choi Jay-Rim
Han Il-Kyu
Lee Mi-Ra
Cho Hwan-Seong
Oh Joo-Han
Kim Han-Soo
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Abstract
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Purpose: This study was performed to investigate the maspin gene expression from osteosarcoma and to determine whether its expression correlates with clinical course of the cancer.
Materials and Methods: Between 2001 and 2006, 39 patients who were diagnosed and treated surgically for osteosarcoma were included in the present study. We estimated the maspin gene expression from osteosarcoma tissue samples using RT-PCR. And we examined the correlations between the maspin expression and clinical data (post-chemotherapeutic response, local relapse or metastases).
Results: Maspin was over expressed in 21 cases of 39 osteosarcoma tissues. There were significant correlations between maspin expression and the response to neoadjuvant chemotherapy, distant metastases & metastasis-free survival. In multivariate analysis, maspin low-expression was significant risk factor for distant metastases. Also, there was significant difference in metastasis-free survivals between maspin hi- expression group (69.0±10.5 %) and low-expression group (25.4±13.0%).
Conclusion: The degree of maspin expression in osteosarcoma was significant risk factor for distant metastases and predictive factor for metastasis-free of overall survivals. Maspin may be a useful biologic marker in evaluating the prognosis in patients with osteosarcoma and could be used as a therapeutic target clinically.
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KEYWORD
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Osteosarcoma, Maspin, RT-PCR, Prognosis
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